Menu
Science blog
Orbital mechanics affect methane levels
Antarctic lake keeps its secrets for now
How snakes lost their legs
Researchers ponder cancer origins
Forming social networks a no-brainer
'Niceness' partly genetic, say scientists
Omega-3 may keep blindness at bay
Coral shines light on rainfall records
Old bone proves Lucy was no swinger
Scientists unlock cosmic ice riddle
Study links pesticides to Parkinson's
Digital world growing faster every year
Energy drinks put kids at risk: report
Robotics speed up cancer drug development
Zinc cuts short the common cold
Counting kicks in at 18 months
NASA spacecraft unravels comet mystery
Astronomers dig up cannibalised galaxy
Study links extreme weather to climate change
Turkey quake gives warning clues
US scientists build first 'antilaser'
Website meltdown leaves scientists fuming
Earth 'unrecognisable' by 2050: experts
Canola fungus genome unravelled
Researchers ponder cancer origins
Cancer could be an 'evolutionary throwback' locked within our genes, linked to the time before we became multicellular animals, according to a new study.

Professor Paul Davies of Arizona State University and Dr Charles Lineweaver of the Australian National University in Canberra, outline their hypothesis in the latest issue of the journal Physical Biology.

The astrobiologists say looking at cancer from an evolutionary viewpoint suggests the mechanisms that lead to cancer are locked in an 'ancient toolkit'. This toolkit comprises of genes that evolved more than a billion years ago when simple, single cells began to co-operate in multicellular organisms.

As multicellular organisms evolved, regulatory genes were 'switched on' causing single cells to stop dividing and become more specialised, for example as liver or blood cells.

It could be that cancer reverses this process, causing cells to 'revert' to a loose-knit co-operation that evolved before multicellular life began, the researchers say.

Lineweaver says the model could be tested by sequencing the genomes of the simplest multicellular life to trace the evolution of these genes.

"Our new model should give oncologists new hope," he says.

"We think that the tumours that develop in cancer patients today take the same form as these simple cellular structures did more than a billion years ago.

"It suggests that cancer is a limited and ultimately predictable adversary."

The researchers point out that genome studies indicate that some of the genes that potentially cause cancer, oncogenes, have an ancient origin.

"Cancer is not a random bunch of selfish rogue cells behaving badly, but a highly efficient pre-programmed response to stress, honed by a long period of evolution," says Davies, Director of the BEYOND: Center for Fundamental Concepts in Science at Arizona State University.
Comparative genomics the next step

Lineweaver says the research is a "new conceptualisation" of what cancer is, and has had a positive reception from oncologists. "All of the factors and adaptations that make cancer seem so complex are ones whose genetic basis evolved billions of years ago," he says.

Professor Nick Hayward, head of the oncogenetics laboratory at the Queensland Institute of Medical Research says the research presents a "novel hypothesis", but needs more genetic information from a range of organisms to be testable.

"What they are proposing is consistent with general views of the cancer stem cell hypothesis, which is that cells revert back to a state where they are able to function in a more pluripotent [capable of affecting more than one organism] rather than a differentiated state."

Hayward says by comparing the genomes of single-celled and multicellular organisms, and identifying genes that have radically changed, they could be tested against the number of known cancer-causing genes.

"That would be a direct test of the hypothesis and would give credence to the model."

Print
Brain efficiency comes from parents
Backward bending light key to stealth
Signs of 'alien life' found in meteorites
Accurate blood test for Down's
Disaster volunteers at risk: study
Elephants smart as chimps, dolphins
Gadgets ruining people's sleep
Why skin doesn't dissolve in the bath
Astronomers find old heads in a young crowd
Paper leads to perfect beer head
Researchers locate brain's loudness map
Jamming may leave GPS in the wilderness
Pain washes guilt away
Quake could alter Tokyo risk: experts
Japan meltdown not like Chernobyl: expert
Dreamtime astronomers understood meteors
CERN restarts search for cosmic origins
Nuclear Contamination: What to Do
Bet-hedging 'key to natural selection'
Humans age same as other primates
US overdue, under-prepared for huge quake
Sperm's egg-seeking secrets revealed
Lasers to nudge space junk out harm's way
Researchers uncover gastro's sugary secret
Kepler probes inside swollen red giant
Randomness could 'improve democracy'
Moonageddon: Apocalypse not
Museum unveils Columbian mammoth
Menu
Ink-jet inspire scientists to make skin
Seaweed offers clues against malaria
Christchurch quakes may be connected
Solar storms pose risk to technology
Study finds fences thwart cane toad
Mobile phone alters brain activity
Sticky dots approved for clinical trial
Humans stink worse than other animals
Putting the bounce in carbon balls
Sulphur secrets uncovered
Cool laser makes atoms march in time
Hot flashes may be a sign of good heart
Scientists see the birth of a new planet
X-ray expectations change search methods
Eucalypt-harming fungus here to stay
Life elements came from outer space
Cricket wimps use perfume to find mates
Orphan planets could support life
Speech lights up visual cortex in blind
How the Sun loses its spots
Cancer resistance mechanism found
Fungus turns Amazonian ants into zombies
Tiny grains record solar system's infancy
Antarctic ice forming beneath glaciers
Visit Statistics
http://google.com/

http://bing.com/

https://gepatit-info.top/

https://serdechnic.com/

https://buy-meds24.com/

https://dverirespekt.ru/

https://www.sribno.net/

https://undergroundcityphoto.com/

https://detskiezabolevaniya.com/

http://grafaman.ru/

http://innoslicon.com/html/product/index.htm

https://yginekologa.com/

https://yes-com.com/

https://www.baikaleminer.com/

https://bitmaein.com/shop

https://www.artdeko.info/

https://aerodizain.com/

http://xn--d1abj0abs9d.in.ua/

http://lider82.ru/

http://sta-grand.ru/

http://snabs.kz/

https://sky-mine.ru/

https://rybalka-opt.ru/

http://snegozaderzhatel.ru/

https://xn--e1aaajzchnkg.ru.com/

http://hit-kino.ru/

http://www.regionshop.biz/

https://xn--80aaafbn2bc2ahdfrfkln6l.xn--p1ai/

https://pp-budpostach.com.ua/

https://vykup-avto-krasnodar.ru/

https://gcup.ru/

https://mega-polis.biz.ua/

http://vanrise.com.ua/

http://infra-e.ru/

https://veterinariya.com/

https://ponosanet.com/

https://cariestop.com/

https://proartrit.com/

https://elonm.ru/

https://nakozhe.com/

https://spinanebolit.com/

http://zameskino.ru/

http://kinoprinc.ru/

http://pospektr.ru/

http://buypillsonline24h.com/

http://komputers-best.ru/

https://komp-pomosch.ru/